The results of a new study show that eating fried food more than four times a week had twice as big an effect on body mass index for those with the highest genetic2 risk scores compared with lower scores. In other words, genetic makeup3 can inflate4 the effects of bad diet, says an accompanying editorial. It is well known that both fried food consumption and genetic variants5 are associated with adiposity6（肥胖） . However, the interaction between these two risk factors in relation to BMI and obesity7 has not been examined.So a team of US researchers, led by Lu Qi, Assistant Professor at Harvard School of Public Health and Brigham and Womens Hospital and Harvard Medical School, analyzed8 interactions between fried food consumption and genetic risk associated with obesity in over 37,000 men and women taking part in three large US health trials.They used food frequency questionnaires to assess fried food consumption and a genetic risk score based on 32 known genetic variants associated with BMI and obesity.Three categories of fried food consumption were identified: less than once a week, one to three times a week, and four or more times a week. Genetic risk scores ranged from 0 to 64 and those with a higher score had a higher BMI.Height and body weight were assessed at the start of the trials, and weight was requested at each follow-up questionnaire. Lifestyle information, such as physical activity and smoking, was also collected.The researchers found consistent interactions between fried food consumption and genetic risk scores on BMI.Among participants in the highest third of the genetic risk score, the differences in BMI between individuals who consumed fried foods four or more times a week and those who consumed less than once a week were 1.0 kg/m2 in women and 0.7 kg/m2 in men.For participants in the lowest third of the genetic risk score, the differences were 0.5 kg/m2 in women and 0.4 kg/m2 in men.The authors stress that their results may have been affected9 by other unmeasured or unknown factors, despite carefully adjusting for several diet and lifestyle factors.However, they say they indicate that the association between fried food consumption and adiposity may vary according to differences in genetic predisposition; and vice10 versa, the genetic influences on adiposity may be modified by fried food consumption.Professor Lu Qi said: Our findings emphasize the importance of reducing fried food consumption in the prevention of obesity, particularly in individuals genetically11 predisposed to adiposity.This work provides formal proof of interaction between a combined genetic risk score and environment in obesity, write Professor Alexandra Blakemore and Dr Jessica Buxton at Imperial College London in an editorial. However, the results are unlikely to influence public health advice, since most of us should be eating fried food more sparingly anyway.In contrast, they stress that genetic information can be very valuable for treating monogenic forms of obesity, caused by changes in a single gene1. They say that it would therefore be a great shame to assume that genetics can be ignored in the management of obesity, and call for further studies providing clinically useful predictions for individuals and enabling stratification of patients for appropriate care and treatment.
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1 gene n.遗传因子，基因 参考例句： A single gene may have many effects.单一基因可能具备非常多种效应。 The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
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